Reviews and Editorials

  • Neuronal γ-secretase regulates synaptic functions via cholesterol homeostasis

    Fu W.Y., Fu A.K.Y. and Ip N.Y.
    Neuron   2023 Oct 18;111(20):3133-3135. doi: 10.1016/j.neuron.2023.09.021.
    [Abstract]    [Full text]

  • Receptor–ligand interaction controls microglial chemotaxis and amelioration of Alzheimer's disease pathology

    Lau S.F., Fu A.K.Y. and Ip N.Y.
    Journal of Neurochemistry   2023;166:891–903. doi: 10.1111/jnc.15933. Epub 2023 Aug 21.
    [Full text]    [Full text]

  • The role of genetic risk factors of Alzheimer's disease in synaptic dysfunction

    Fu W.Y. and Ip N.Y.
    Semin Cell Dev Biol.   2022 Jul 30:S1084-9521(22)00240-3. doi: 10.1016/j.semcdb.2022.07.011.
    [Full text]    [Full text]

  • Instructive roles of astrocytes in hippocampal synaptic plasticity: neuronal activity-dependent regulatory mechanisms

    Wang Y., Fu A.K.Y. and Ip N.Y.
    FEBS J.   2022 Apr;289(8):2202-2218. doi: 10.1111/febs.15878. Epub 2021 May 10.
    [Full text]    [Full text]

  • IL-33/ST2 Signaling Regulates Synaptic Plasticity and Homeostasis in the Adult Hippocampal Circuitry

    Wang Y., Fu A.K.Y. and Ip N.Y.
    DNA Cell Biol. 2021   Sep;40(9):1125-1130. doi: 10.1089/dna.2021.0491. Epub 2021 Jul 22. PMID: 34297618
    [Full text]    [Full text]

  • Retinal Dysfunction in Alzheimer's Disease and Implications for Biomarkers

    Liao C., Xu J., Chen Y. and Ip N.Y.
    Biomolecules.    2021 Aug 16;11(8):1215. doi: 10.3390/biom11081215
    [Full text]    [Full text]

  • Instructive roles of astrocytes in hippocampal synaptic plasticity: neuronal activity-dependent regulatory mechanisms

    Wang Y., Fu A.K.Y. and Ip N.Y.
    FEBS J.   2021 Apr 17. doi: 10.1111/febs.15878.
    [Full text]    [Full text]

  • Cytokine signaling convergence regulates the microglial state transition in Alzheimer's disease

    Lau S.F., Fu A.K.Y. and Ip N.Y.
    Cell Mol Life Sci.   2021 Apr 13. doi: 10.1007/s00018-021-03810-0.
    [Full text]    [Full text]

  • APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention

    Zhou X., Fu A.K.Y. and Ip N.Y.
    Curr Opin Neurobiol.   2021 Feb 26;69:58-67. doi: 10.1016/j.conb.2021.02.001.
    [Full text]    [Full text]

  • Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies

    Chen Y., Fu A.K.Y. and Ip N.Y.
    Pharmacol Ther.   2018 Nov 12. pii: S0163-7258(18)30203-1. doi: 10.1016/j.pharmthera.2018.11.006.
    [Full text]    [Full text]

  • Targeting Neuroinflammation as a Therapeutic Strategy for Alzheimer's Disease: Mechanisms, Drug Candidates, and New Opportunities

    Fu W.Y., Wang X. and Ip N.Y.
    ACS Chem Neurosci.  2018 Sep 17. doi: 10.1021/acschemneuro.8b00402.
    [Full text]    [Full text]

  • Finding success by following your heart

    Ip N.Y.
    Nat. Cell Biol.   2018 Sep;20(9):1003. doi: 10.1038/s41556-018-0159-3.
    [Full text]    [Full text]

  • Homeostatic Scaling of AMPA Receptors by Semaphorin

    Fu A.K.Y. and Ip N.Y.
    Neuron   2017 Dec 6;96(5):955-958. doi: 10.1016/j.neuron.2017.11.025.
    [Abstract]    [Full text]

  • Regulation of postsynaptic signaling in structural synaptic plasticity

    Fu A.K.Y. and Ip N.Y.
    Curr. Opin. Neurobiol.   2017 Jun 7;45:148-155. doi: 10.1016/j.conb.2017.05.016.
    [Abstract]    [Full text]

  • Plant alkaloids as drug leads for Alzheimer's disease

    Ng Y.P., Cho T., Or T. and Ip N.Y.
    Neurochem Int.   2015 Jul 25. pii: S0197-0186(15)30020-6. doi: 10.1016/j.neuint.2015.07.018.
    [Abstract]    [Full text]

  • Emerging roles of Axin in cerebral cortical development

    Ye T., Fu A.K.Y. and Ip N.Y.
    Front Cell Neurosci.   2015 Jun 8;9:217. doi: 10.3389/fncel.2015.00217. eCollection 2015.
    [Abstract]    [Full text]

  • Toward New Therapies

    Karl Broich, David M. Holtzman, Ip N.Y., Edward Koo, Walter J. Koroshetz, Eliezer Masliah, Lennart Mucke, Pierluigi Nicotera, Menekas N. Pangalos, Mareike Schnaars, Maria Grazia Spillantini, Karoly Nikolich
    Translational Neuroscience (ed. Karoly Nikolich and Steven E. Hyman). Strüngmann Forum Reports   Vol. 17, series ed. J. Lupp. Cambridge, MA: MIT Press. Invited.
    [Reference list]

  • Editorial: Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function

    Yoshii A., Constantine-Paton M. and Ip N.Y.
    Front Synaptic Neurosci.   2015 Jun 4; 7:8. doi: 10.3389/fnsyn.2015.00008. eCollection 2015.
    [Abstract]    [Full text]

  • Cdk5: a key player at neuronal synapse with diverse functions

    Lai K.O. and Ip N.Y.
    Mini Rev. Med. Chem.   2015 Mar 24
    [Abstract]   

  • Neddylation is needed for synapse maturation

    Fu A.K.Y. and Ip N.Y.
    Nat. Neurosci.   2015 Feb; 18(2): 164-6.
    [Abstract]    [Full text]

  • CRMP2: Functional roles in neural development and therapeutic potential in neurological diseases

    Ip J.P., Fu A.K.Y. and Ip N.Y.
    Neuroscientist   2014 Dec; 20(6):589-98. doi: 10.1177/1073858413514278. Epub 2014 Jan 8.
    [Full text]

  • Cyclin-dependent kinase 5 in axon growth and regeneration

    Ye T., Fu A.K.Y. and Ip N.Y.
    Int Rev Neurobiol.   2012;105:91-115.
    [Abstract]   

  • Eph receptors at synapses: Implications in neurodegenerative disease

    Chen Y., Fu, A.K.Y. and Ip N.Y.
    Cellular Signaling   24:606-611. Invited
    [Full text]    [F1000 Prime Recommended]

  • Cdk5: a multifaceted kinase in neurodegenerative diseases

    Cheung Z.H. and Ip N.Y.
    Trends Cell Biol.   846:1-7. Invited.
    [Full text]

  • Eph receptor

    Lai K.O. and Ip N.Y.
    Encyclopedia of Signaling Molecules   Springer, P.560-567. Invited.

  • Career development for women scientists in Asia

    Ip N.Y.
    Neuron   70:1029-1032.4.
    [Full text]

  • Cyclin-dependent kinase 5 – an emerging player in Parkinson's disease pathophysiology

    Cheung Z.H. and Ip N.Y.
    Parkinson's Disease / Book six   P.141-156. Invited.

  • Neurotrophic factors

    Ip N.Y. and Lu B.
    Neuroscience   (3rd edition) (ed. J-S Han, M-M Poo and Y Rao), 26:474-489. Invited.

  • Endophilin B1: Guarding the gate to destruction

    Cheung Z.H. and Ip N.Y.
    Communicative and Integrative Biology   2: 130-132. Invited.
    [Full text]

  • Synapse formation and plasticity: roles of ephrin/Eph receptor signaling

    Lai K.O. and Ip N.Y.
    Current Opinion in Neurobiology   19: 275-283. Invited.
    [Full text]

  • Recent advances in understanding the roles of Cdk5 in synaptic plasticity

    Lai K.O. and Ip N.Y.
    Biochimica et Biophysica Acta   1792: 741-745. Invited.
    [Full text]

  • Bidirectional signaling of ErbB and Eph receptors at synapses

    Chen Y., Fu, A.K.Y. and Ip N.Y.
    Neuron Glia Biol.   4: 211-221. Invited.
    [Full text]

  • The emerging role of autophagy in Parkinson's disease

    Cheung Z.H. and Ip N.Y.
    Mol. Brain   2: 29. Invited.
    [Full text]

  • β-catenin in reverse action

    Fu A.K.Y., Cheung Z.H. and Ip N.Y.
    Nat. Neurosci.   11: 244-246.
    [Full text]

  • Cdk5 in dendrite and synapse development: emerging role as a modulator of receptor tyrosine kinase signaling

    Cheung Z.H. and Ip N.Y.
    Cyclin Dependent Kinase 5 (Cdk5)   (ed. N.Y Ip and L.-H. Tsai), Springer Science+Business Media, LLC, P51-68.

  • CDK5, in Targeted Proteins Database

    Fu A.K.Y. and Ip N.Y.
    /1, [22945], 10.2970/tpdb.2009.264. Invited.

  • Neurotrophins – players in the regulation of neuronal survival and apoptosis

    Cheung Z.H. and Ip N.Y.
    Current Science   95: 1237-1251. Invited.
    [Full text]

  • Biotech News on Hong Kong

    Ip N.Y.
    Asia Pacific Biotech News   11(4): 218-220.

  • The roles of cyclin-dependent kinase 5 in dendrite and synapse development

    Cheung Z.H. and Ip N.Y.
    Biotechnology Journal   2: 949-957. Invited.
    [Full text]

  • Cyclin-dependent kinase 5 links extracellular cues to actin cytoskeleton during dendritic spine development

    Fu A.K.Y. and Ip N.Y.
    Cell Adhesion & Migration   1:2, 110-112. Invited.
    [Full text]

  • Signaling through the neurotrophin receptors in the nervous system

    Ng Y.P., Lo K.Y., Cheung Z.H. and Ip N.Y.
    Handbook of Neurochemistry   2:12-32. Invited review.

  • Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases

    Cheung Z.H., Fu A.K.Y. and Ip N.Y.
    Neuron   50: 13-18. Invited review.
    [Full text]

  • Modernization of traditional Chinese medicine in Hong Kong

    Ip N.Y.
    Biotechnology in Hong Kong   (ed. A. W.-K. Chan), United States-China Intellectual Property Institute publ., P. 30-53. Invited.

  • Central synapse and neuromuscular junction: same players, different roles

    Lai K.O. and Ip N.Y.
    Trends in Genetics   19: 395-402. Invited.
    [Full text]

  • Cdk5: A new player at synapses

    Cheng K. and Ip N.Y.
    NeuroSignals   12: 180-190. Invited.
    [Full text]

  • Postsynaptic signaling of new players at the neuromuscular junction

    Lai K.O. and Ip N.Y.
    J. Neurocytol.   32: 727-741. Invited.
    [Full text]

  • Surface characterization of DNA microarray on silicon dioxide and compatible silicon materials in the immobilization process

    Xu W., Li J., Xue M., Carles, M., Wilhelm Trau, D., Lenigk, R., Sucher, N.J., Ip N.Y. and Chan M.
    Materials Research Society Symposium – Proceedings   711: 25-30.

  • Integration of signals from receptor tyrosine kinases and G-protein-coupled receptors

    Lowes, V., Ip N.Y. and Wong Y.H.
    NeuroSignals   11: 5-19.
    [Full text]

  • Biotechnology in Hong Kong

    Kung S.D., Wong J.T.F. and Ip N.Y.
    International Journal for Technology Management   2: 355-363. Invited.

  • Chips and Qi: Microcomponent Based Analysis in Traditional Chinese Medicine

    Carles, M., Lee T., Moganti, S., Lenigk, R., Tsim K.W.K., Ip N.Y., Hsing I., and Sucher, N.J.
    Fresenius J. Analytical Chem.   371: 190-194. Invited.

  • Hong Kong - An emerging hub for Traditional Chinese Medicine

    Chao L.C.F., and Ip N.Y.
    Bio/Pharma Quarterly   5: 11-13. Invited.

  • Biotechnology finds its way to Hong Kong

    Kung S.D., Wong J.T.F. and Ip N.Y.
    International Journal of Biotechnology   2: 355-363. Invited.

  • Biological and genetic therapy for brain injury

    Tang H. and Ip N.Y.
    Molecular Surgery and Gene Therapy   pp. 146-162.

  • The neurotrophins and neuropoietic cytokines: two families of growth factors acting on neural and immune cells

    Ip N.Y.
    Annals NY Acad. Sci.   840: 115-126.
    [Full text]

  • Interaction of neurotrophins and retinoic acid in neuronal differentiation

    Cheung W.M.W. and Ip N.Y.
    Mol. Cells   8: 496-502. Invited.

  • A molecular biology network for Asia and the Pacific Rim

    Ip N.Y. and Shahi, G.
    Science   280: 1708.
    [Full text]

  • The 6th Pacific Rim Biotechnology Conference and BioExpo 98 meets in Hong Kong SAR

    Chao L. and Ip N.Y.
    Asia Pacific Biotech News   2: 295-299. Invited.

  • Modernization of traditional Chinese medicine in Hong Kong

    Ip N.Y.
    Biotechnology in Hong Kong   (ed. A. W.-K. Chan), United States-China Intellectual Property Institute publ., pp. 19-49. Invited.

  • The neurotrophins and CNTF: Two families of collaborative neurotrophic factors

    Ip N.Y. and Yancopoulos, G.D.
    Ann. Rev. Neurosci.   19: 491-515. Invited.

  • Neurotrophic factors and their receptors

    Ip N.Y. and Yancopoulos, G.D.
    Annals of Neurology   35: S13-S16.

  • Neurotrophic factor receptors: just like other growth factor and cytokine receptors?

    Ip N.Y. and Yancopoulos, G.D.
    Current Opinion in Neurobiology   4: 400-405. Invited.

  • Receptors and signaling pathways of ciliary neurotrophic factor and the neurotrophins

    Ip N.Y. and Yancopoulos, G.D.
    Seminars in The Neurosciences   5: 249-257. Invited.

  • Neurotrophin-4 or Neurotrophin-5?

    Ip N.Y. and Yancopoulos, G.D.
    Neuroscience Facts   3: 2-3. Invited.

  • Ciliary neurotrophic factor and its receptor complex

    Ip N.Y. and Yancopoulos, G.D.
    Prog. Growth Factor Res   4: 139-155. Invited.

  • Cholinergic and peptidergic regulation of ganglionic tyrosine hydroxylase activity

    Zigmond, R.E. and Ip N.Y.
    Dynamics of Cholinergic Function   Hanin, I., Ed., Plenum Press, N.Y., pp. 1039-1045.